Full list of publications:
SenNet Consortium. NIH SenNet Consortium to map senescent cells throughout the human lifespan to understand physiological health. Nature Aging. 2022 2 1090–1100.
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Onorati A, Havas AP, Lin B, Rajagopal J, Sen P, Peter D. Adams PD, Dou Z. Upregulation of PD-L1 in senescence and aging. Mol Cell Biol. 2022 Sep 26:e0017122.
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Wang Y, Eapen VV, Kournoutis A, Onorati A, Li X, Zhou X, Cetinbas M, Wang L, Liu J, Bretz C, Zhou Z, Sui SH, Sadreyev RI, Adams PD, Kingston RE, Yue Z, Johansen T*, Dou Z* (*co-corresponding authors). Nuclear autophagy interactome unveils WSTF as a constitutive nuclear inhibitor of inflammation. bioRxiv. 2022.
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Wang L, Dou Z. Apolipoprotein E regulates chromatin stability and senescence. Nature Aging. 2022 2, 282–284. News and Views.
Zhou Z, Zhang X, Lei X, Xiao X, Jiao T, Ma R, Dong X, Jiang Q, Wang W, Shi Y, Zheng T, Rao J, Xiang Z, Ren L, Deng T, Jiang Z, Dou Z, Wei W, Wang J. Sensing of cytoplasmic chromatin by cGAS activates innate immune response in SARS-CoV-2 infection. Signal Transduct Target Ther. 2021 Nov 3;6(1):382.
Xu C, Wang L, Fozouni P, Evjen G, Chandra V, Jiang J, Lu C, Nicastri M, Bretz C, Winkler JD, Amaravadi R, Benjamin GA, Adams PD, Ott M, Tong W, Johansen T, Dou Z*, Berger SL* ​ (co-corresponding authors). SIRT1 is downregulated by autophagy in senescence and aging. Nature Cell Biology. 2020. Sept 28.
Vizioli MG, Liu T, Miller KN, Robertson NA, Gilroy K, Lagnado AB, Perez-Garcia A, Kiourtis C, Dasgupta N, Lei X, Kruger PJ, Nixon C, Clark W, Jurk D, Bird TG, Passos JF, Berger SL, Dou Z*, Adams PD* (co-corresponding authors).
Dou Z*, Berger SL* (co-corresponding authors). Senescence Elicits Stemness: A Surprising Mechanism for Cancer Relapse. Cell Metab. 2018 Apr 3;27(4):710-711.
Dou Z, Ghosh K, Vizioli MG, Zhu J, Sen P, Wangensteen KJ, Simithy J, Lan Y, Lin Y, Zhou Z, Capell BC, Xu C, Xu M, Kieckhaefer JE, Jiang T, Shoshkes-Carmel M, Tanim KM, Barber G, Seykora JT, Millar SE, Kaestner KH, Garcia BA, Adams PD, Berger SL. Cytoplasmic chromatin triggers inflammation in senescence and cancer. Nature. 2017 Oct 19;550(7676):402-406.
Dou Z, Xu C, Donahue G, Shimi T, Pan JA, Zhu J, Ivanov A, Capell BC, Drake AM, Shah PP, Catanzaro JM, Ricketts MD, Lamark T, Adam SA, Marmorstein R, Zong WX, Johansen T, Goldman RD, Adams PD, Berger SL. Autophagy mediates degradation of nuclear lamina. Nature. 2015 Nov 5;527(7576):105-9.
Zhu J, Sammons MA, Donahue G, Dou Z, Vedadi M, Getlik M, Barsyte-Lovejoy D, Al-Awar R, Katona BW, Shilatifard A, Huang J, Hua X, Arrowsmith CH, Berger SL. Gain-of-function p53 mutants co-opt chromatin pathways to drive cancer growth. Nature. 2015 Sep 10;525(7568):206-11.
Dou Z, Pan JA, Dbouk HA, Ballou LM, Deleon JL, Fan Y, Chen JS, Liang Z, Li G, Backer JM, Lin RZ, Zong WX. Class IA PI3K p110β subunit promotes autophagy through Rab5 small GTPase in response to growth factor limitation. Molecular Cell. 2013 Apr 11;50(1):29-42.
Jaber N, Dou Z, Chen JS, Catanzaro JM, Jiang YP, Ballou LM, Selinger E, Ouyang X, Lin RZ, Zhang J, Zong WX. The Class III PI3K Vps34 plays an essential role in autophagy and in the heart and liver function. PNAS. 2012 Feb 7;109(6):2003-8.