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Zhixun Dou, Ph.D.


Principal Investigator

          Dou joined MGH and Harvard in 2018 fall. He received his B.S. from Nankai University, China, working with Youjia Cao, and his Ph.D. from Stony Brook University, Wei-Xing Zong lab. He trained with Shelley Berger at University of Pennsylvania for postdoc, where he pioneered the study of nuclear degeneration in aging and cancer. He is a recipient of the NIH pathway to independence award. 

          Outside the lab, he is a husband and a father of two daughters (and a cat). He loves classical music, and believes that healthy eating and good mental health are key to longevity.

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Angelique Onorati 

Lab Manager

          Angelique joined the Dou Laboratory in 2018 fall. She received her A.S. from County College of Morris and her B.A. in Biology with a minor in Hispanic Studies from University of Pennsylvania. At Penn, she worked in Dr. Ravi  Amaravadi's laboratory focusing on autophagy in cancer biology.

          Outside the lab, she enjoys traveling and adventuring with her beagle. She loves dancing, especially the Argentinian Tango. She believes that smiling and exercising are key to longevity.

Yuting Tan, Ph.D.

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Post-doctoral research fellow

          Yuting was trained as a Ph.D. at University of California, San Francisco and Shanghai Jiao Tong University. During her PhD research, she studied the epigenetic mechanisms of acute myeloid leukemia as well as the differentiation of induced pluripotent stem cells into hematopoietic stem and progenitor cells. Her research interests broadly involve in cancer, stem cell and aging. She joined the Dou Laboratory in 2019 fall.

          Outside the lab, she enjoys reading books related to philosophy. She believes even though life is as the metaphor of Myth of Sisyphus, the fundamental impulse to understand the universe underlies the reasons for why life is worth living. She believes that contemplation and exercising are key to healthy longevity.

Yu Wang, Ph.D.

Post-doctoral research fellow

          Yu joined Dou Laboratory at MGH and Harvard in the fall of 2018. His Ph.D. was trained in the Junying Yuan lab at Harvard Medical School and Haoran Lin lab at Sun Yat-sen University, focusing on understanding the mechanisms of regulating cell survival and death. Now Yu is working on the roles of selective nuclear autophagy in cell signaling and disease mechanisms in both Dou lab at MGH and Harvard, and Terje Johansen lab at the Arctic University of Norway.

          Outside the lab, he enjoys playing basketball and watching NBA games. Kyrie Irving is his favorite basketball player, and he is a big fan of the Boston Celtics. Yu also enjoys listening to pop music and believes a positive mindset is a key to a meaningful life.

Takuya Kumazawa, Ph.D.

Research fellow

         Takuya studied the regulation of energy metabolism controlled by the nucleolus during his Ph.D. program at the University of Tsukuba, Japan. After he moved to Nara Medical University, he investigated the relationship between cellular senescence and the nucleolus. Through these studies, he has become interested in the nucleolus-mediated cellular senescence in vivo. Then he found nucleolus-mediated cellular senescence and SASP trigger heart failure.

         Outside the lab, he loves traveling, beer and good food. He plans to enjoy craft beer in all 50 states. He also enjoys kendo and karaoke and believes happiness is the key to longevity.

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